Orphenadrine citrate

Brand names Biorphen, Disipal, Norflex .

Used in the following combined preparations

None

general information

Orphenadrine is an anticholinergic drug that is prescribed to treat all forms of Parkinson'sdisease. Although it is less effective than other drugs used in the treatment of this disorder, it is often preferred because its adverse effects tend to be less severe. Orphenadrine is particularly valuable for relieving the muscle rigidity that often occurs with Parkinson's disease; it is less helpful for improving slowing of movement that also commonly affects sufferers.

Effervescent Tablets-Kamagra Effervescent

Orphenadrine possesses significant muscle-relaxant properties. It produces this effect by blocking nerve pathways responsible for muscle rigidity and spasm. Consequently, it is prescribed for the relief of muscle spasm caused by muscle injury, prolapsed ("slipped") disc, and whiplash injuries.

information for users

Your drug prescription is tailored for you. Do not alter dosage without checking with your doctor.

How taken

Tablets, liquid, injection.

Frequency and timing of doses

2-3 x daily.

Adult dosage range

150-400mg daily.

Onset of effect

Within 60 minutes (by mouth); within 5 minutes (by injection).

Duration of action

8-12 hours.

Diet advice

None.

Storage

Keep in a closed container in a cool, dry place out of the reach of children. Protect from light.

Missed dose

Take as soon as you remember. If your next dose is due within 2 hours, take a single dose now and skip the next.

Stopping the drug

Do not stop the drug without consulting your doctor; symptoms may recur.

overdose action

Seek immediate medical advice in all cases. Take emergency action if palpitations, fits, or loss of consciousness occur.

See Drug poisoning emergency guide.

possible adverse effects

The adverse effects of orphenadrine are similar to those of other anticholinergic drugs. The more common symptoms,

such as dryness of the mouth and blurred vision, can often be overcome by an adjustment in dosage.

Symptom/effect	Frequency Common	Rare	Discus; doctor Only if severe	with In all cases	Stop taking drug now	Call doctor now
Dry mouth/skin	•		■
Difficulty passing urine	•		■
Constipation	•		■
Dizziness	•		■
Blurred vision	•			■
Confusion/agitation		•		■
Rash/itching		•		■	▲
Palpitations		•		■	▲	1

interactions

Anticholinergic drugs The anticholinergic effects of orphenadrine are likely to be increased by these drugs.

Dextropropoxyphene and co-proxamol

Confusion, anxiety, and tremors may occur if these drugs are taken with orphenadrine.

Sedatives The effects of all drugs that have a sedative effect on the central nervous system are likely to be increased with orphenadrine.

quick reference

Drug group Anticholinergic muscle relaxant and drug for parkinsonism .

Overdose danger rating High

Dependence rating Low

Prescription needed Yes

Available as generic Yes

special precautions

Be sure to tell your doctor if:

▼      You have long-term liver or kidney problems.

▼      You have heart problems.

▼      You have had glaucoma.

▼      You have difficulty passing urine.

▼      You have myasthenia gravis.

  You are taking other medications.

Pregnancy

▼       Safety in pregnancy not established. Discuss with your doctor.

Breast-feeding

▼       The drug passes into the breast milk, but at normal doses adverse effects on the baby are unlikely. Discuss with your doctor.

Infants and children

▼       Not usually prescribed.

Over 60

▼     Increased likelihood of adverse effects. Reduced dose may therefore be necessary.

Driving and hazardous work

▼     Avoid such activities until you have learned how orphenadrine affects you because the drug can cause dizziness, lightheadedness, and blurred vision.

Alcohol

  Avoid. Alcohol may increase the sedative effects of this drug.

prolonged use

No problems expected. Effectiveness in treating Parkinson's disease may diminish with time.